|
Squamous cell carcinoma of esophagus
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In brief, our study shows that overexpression of PTTG in ESCC is likely due to the activation of beta-catenin/WNT signaling.
|
15514942 |
2005 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic β-catenin expression in ESCC tissues.
|
25217103 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we demonstrated that GPC1 increased levels of p-Akt and β-catenin and reduced PTEN expression in ESCC.
|
30730015 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression levels of zinc finger protein SNAI1 (Snail) and β‑catenin in ESCC were significantly higher compared with para-carcinoma tissues, whereas E‑cadherin mRNA and protein expression levels were lower in ESCC tissues compared with in para-carcinoma tissues.
|
28260072 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In the vitro experiments, knocking down the expression of PBR inhibited proliferation, colony formation and migration of ESCC cells, and regulated EMT-associated proteins (up-regulation of E-cadherin, ZO-1 and β-catenin and concomitant with down-regulation of Fibronectin and N-cadherin).
|
29158807 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
<b>Methods:</b> qRT-PCR was used to detect the levels of FEZF1-AS1 and mRNA CTNNB1 (β-catenin) in ESCC tissues and cells.
|
31191005 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We immunohistochemically examined the expression of MMP-7 and beta-catenin to better understand the significance of these factors in the progression of esophageal squamous cell carcinoma.
|
12498294 |
2002 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Krüppel-like factor 9 was down-regulated in esophageal squamous cell carcinoma and negatively regulated beta-catenin/TCF signaling.
|
25641762 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The results of this study suggest that matrilysin-2, the expression of which is closely correlated with nuclear beta-catenin expression and active MMP-9 activity, plays a key role in the progression of ESCC.
|
15333466 |
2004 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of Wnt1/beta-catenin mRNA should also predict poor prognosis of ESCC; however, it might not be an independent prognostic factor.
|
20491588 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of WIF1 in NPC and ESCC tumor cells resulted in significant inhibition of tumor cell colony formation, similar to TP53, and also significant downregulation of beta-catenin protein level in NPC cells.
|
17384664 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A comparison of extracellular stimuli suggests that specific Wnt family members stabilize beta-catenin with resulting activation of TCF-dependent transcription in ESCC.
|
11782388 |
2002 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
When placed in stable transfectants of the KYSE 30 ESCC cell line generated by lentiviral transduction with the ectopic overexpression of NDRG1, the expression of transducin-like enhancer of Split 2 (TLE2) was decreased sharply, however β-catenin was increased.
|
27414086 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Silencing circRNA_100367 inhibited the proliferation and migration of KYSE-150R cells, and decreased the expression of β-catenin (an important molecule in Wnt pathway) in KYSE-150R cells.
|
31851619 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
beta-catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome.
|
11193470 |
2000 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Beta-catenin expression in ESCC is of great importance.
|
17552014 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the expression pattern of E-cadherin, alpha-catenin and beta-catenin in 22 cases of esophageal squamous-cell carcinoma by Western-blot analysis.
|
10709091 |
2000 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with beta-catenin cytoplasmic/nuclear accumulation.
|
18602747 |
2008 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mechanically, we demonstrated PRR11-enhanced tumorigenicity of ESCC cells via activating Wnt/β-catenin signaling, and PRR11 expression is found to be significantly correlated with β-catenin nuclear location in ESCC.
|
31040705 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
|
31278587 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway.
|
25749389 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> SOX2, β-catenin and survivin can be used as prognostic markers of esophageal squamous cell carcinoma.
|
31789057 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway.
|
31638260 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, these results revealed that the interaction of CTGF and beta-catenin-TCF/Lef forms a positive feedback loop, which could contribute to the tumorigenicity of ESCC.
|
17951630 |
2007 |